Apple Procyanidins Suppress Amyloidβ-Protein Aggregation
نویسندگان
چکیده
منابع مشابه
Apple Procyanidins Suppress Amyloid β-Protein Aggregation
Procyanidins (PCs) are major components of the apple polyphenols (APs). We previously reported that treatment with PC extended the mean lifespan of Caenorhabditis elegans (Sunagawa et al., 2011). In order to estimate the neuroprotective effects of PC, we investigated the antiaggregative activity of PC on amyloid β-protein (Aβ) aggregation, which is a pathological hallmark of Alzheimer's disease...
متن کاملSynergism between apple procyanidins and lysosomotropic drugs: potential in chemoprevention.
BACKGROUND Procyanidins are apple constituents with potential in colon cancer chemoprevention. MATERIALS AND METHODS Human colon cancer derived metastatic cells (SW620), growing under standardized conditions, were exposed to procyanidins and lysosomotropic compounds. Growth, apoptosis and lysosomal integrity was determined using published methods. RESULTS Lysosomotropic drugs (MDL 72527, ph...
متن کاملCocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase.
Cocoa was shown to inhibit chemically induced carcinogenesis in animals and exert antioxidant activity in humans. However, the molecular mechanisms of the chemopreventive potential of cocoa and its active ingredient(s) remain unknown. Here we report that cocoa procyanidins inhibit neoplastic cell transformation by suppressing the kinase activity of mitogen-activated protein kinase kinase (MEK)....
متن کاملApple procyanidins induce tumor cell apoptosis through mitochondrial pathway activation of caspase-3.
Various epidemiologic and experimental in vivo and in vitro studies have suggested that polyphenols derived from fruits, vegetables and beverages might decrease the risk of developing lifestyle diseases, such as cardiovascular disorders and cancer. Apples are a major dietary source of polyphenols. Here we investigated the antitumor activity of apple polyphenols (APs) and procyanidins, namely co...
متن کاملOral delivery of oligomeric procyanidins in Apple Poly® enhances type I IFN responses in vivo.
Type I IFN signaling is a central pathway that provides critical innate protection from viral and bacterial infection and can have regulatory outcomes in inflammatory settings. We determined previously that OPCs contained in the dietary supplement APP enhanced responses to type I IFN in vitro. Here, we confirm that OPCs from two different sources significantly increased pSTAT1, whereas a monome...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemistry Research International
سال: 2011
ISSN: 2090-2247,2090-2255
DOI: 10.1155/2011/784698